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The Shimadzu CLAM-2040 is an automated clinical laboratory automation module that streamlines LC-MS/MS sample preparation for high-throughput laboratories. Designed for 24/7 operation, it enables fully unattended workflows from sample receipt to injection. The system accommodates blood, plasma, and urine samples, offering automated protein precipitation, mixing, and filtration to ensure reproducibility. With capacity for up to 60 samples per batch, it reduces manual handling and risk of errors. The CLAM-2040 features integrated barcode reading, LIS connectivity, and user-friendly software, making it ideal for clinical research, forensic toxicology, and pharmaceutical testing.